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REVIEW ARTICLE
Year : 2022  |  Volume : 8  |  Issue : 2  |  Page : 90-94

Biochemical mechanism of ferroptosis-mediated cancer cell death in triple-negative breast cancer: An insight


1 Department of Biochemistry, Government Arts and Science College, Orathanadu, Thanjavur, Tamil Nadu, India
2 Department of Biochemistry, Government Arts and Science College, Srirangam, Tiruchirappalli, Tamil Nadu, India
3 Department of Pharmaceutical Engineering, Aarupadai Veedu Institute of Technology, Paiyanoor, Kancheepuram District, Tamil Nadu, India
4 Department of General Surgery, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India
5 Department of Biochemistry, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India
6 Department of Central Research Facility, Santosh Deemed to be University, Ghaziabad, Uttar Pradesh, India

Correspondence Address:
Sivanesan Dhandayuthapani
Central Research Facility Santosh, Deemed to be University, Ghaziabad, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/sujhs.sujhs_37_22

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Ferroptosis is a form of programmed cell death (PCD), distinct from apoptosis, that was identified in 2012. The process is driven by the iron-dependent oxidative degeneration of lipids. Ferroptosis causes cell death through the accumulation of iron-dependent lipid reactive oxygen species. Free radicals cause degradation of lipid molecules by the removal of electrons through oxidation. The process is dependent on intracellular iron as the accumulation of iron acts as a catalyst for converting peroxides into free radicals. The oxidative degradation of lipids occurs when there is depletion of the antioxidant glutathione and a loss of activity of the lipid repair enzyme glutathione peroxidase 4. The lipid peroxidation then leads to cell membrane denaturation. The biochemical mechanism behind the unique iron-dependent programmed cell death with reference to the triple negative breast cancer have been reviewed in this article.


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